A year after CA went into lockdown, Patrick Joseph, M.D., Chair of Infection Control at San Ramon Regional Medical Center presents “What we know now about COVID-19,” including how the vaccines work and what is known at this time about variants, how well vaccines protect against variants, and what people who are vaccinated can safely do. This is a timely topic as public agencies, organizations, and businesses are contending with the complexity of new information and guidance as they work on how to safely reopen and begin returning to normal life.